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I don’t have a single favorite one, so here is a top three, in no particular order:
Freefall The first webcomic i read, started in 1998 and still updating three times a week.
El Goonish Shive Another longrunner, started 2002 and still going. Helped me with figuring out some gender stuff.
How to be a werewolf Newest one on the list, starting in 2015, also still going.
XKCD
Calvin & Hobbes I guess doesn’t count.
That looks great!
The collaborative open source approach is very interesting too